منابع مشابه
Rearrangement of 14/3-Hydroxy-12ß-sulfoxy-steroids to 13,17-Seco-12,17-cyclo-steroids; a 2D-NMR Analysis
During our work on cardiaoctive steroids we studied the elimination of the 12/3-sulfoxy-group. It is well known that 12/J-tosyloxyor 12/3-mesyloxysteroids with C/D-trans juncture undergo elimination to yield C-nor-D-homo steroids with 12(13) or 13(18) double bonds [1—6]. The same rearrangement product was obtained by the reaction of a 12/3-tosyloxycardenolide [7] with C/D-eis juncture. No GrobF...
متن کاملMicrobial Hydroxylation of 16α, 17α-Epoxyprogesterone by Penicillium Decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کامل1β,15α-Dihydroxy-16α,17-epoxypregn-4-ene-3,20-dione
The title mol-ecule, C21H28O5, is composed of three six-membered rings (A/B/C) and a five-membered ring (D). Ring A adopts a 1α-sofa conformation, while rings B and C adopt chair conformations. Cyclo-pentane ring D adopts a 14α-envelope conformation. In the crystal, O-H⋯O hydrogen bonds lead to the formation of ribbons running along the a axis. The structure is further consolidated by C-H⋯O int...
متن کاملMicrobial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملRegio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3.
Cytochrome P450 monooxygenases (P450s), which constitute a superfamily of heme-containing proteins, catalyze the direct oxidation of a variety of compounds in a regio- and stereospecific manner; therefore, they are promising catalysts for use in the oxyfunctionalization of chemicals. In the course of our comprehensive substrate screening for all 27 putative P450s encoded by the Streptomyces gri...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69461-x